Cleveland Clinic researchers have made a groundbreaking discovery, identifying a new pathway that links excess niacin to cardiovascular disease. The study, led by Dr. Stanley Hazen, found that the breakdown product 4PY from excess niacin is strongly associated with heart attacks, strokes, and other adverse cardiac events.
Preclinical studies revealed that 4PY triggers vascular inflammation, leading to the development of atherosclerosis. This discovery opens up new possibilities for interventions and therapeutics aimed at reducing inflammation and preventing cardiovascular disease.
The research also raises concerns about the fortification of niacin in staple foods, which may be contributing to high levels of 4PY in some individuals. Dr. Hazen suggests that individuals consult with their doctors before taking over-the-counter niacin supplements, as the study sheds light on why niacin is no longer commonly used to lower cholesterol.
Furthermore, the study emphasizes the need for long-term investigations to assess the effects of chronic elevation of 4PY levels on atherosclerosis. This research is part of ongoing investigations into factors contributing to residual cardiovascular risk led by Dr. Hazen at Cleveland Clinic.
The findings from this study have significant implications for public health, as they challenge the current mandate of niacin fortification in the U.S. It is clear that more research is needed to fully understand the impact of excess niacin on cardiovascular health and to develop effective strategies for prevention and treatment.
